Radiosynthesis and Preclinical Evaluation of [(18)F]F-DPA, A Novel Pyrazolo[1,5a]pyrimidine Acetamide TSPO Radioligand, in Healthy Sprague Dawley Rats

PURPOSE: Many neurological conditions result in the overexpression of the translocator protein 18 kDa (TSPO), today recognized as a biomarker for microglial activation and neuroinflammation imaging. The pyrazolo[1,5-a]pyrimidine acetamides are a particularly attractive class of TSPO-specific ligands...

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Detalles Bibliográficos
Autores principales: Keller, Thomas, Krzyczmonik, Anna, Forsback, Sarita, Picón, Francisco R. López, Kirjavainen, Anna K., Takkinen, Jatta, Rajander, Johan, Cacheux, Fanny, Damont, Annelaure, Dollé, Frédéric, Rinne, Juha O., Haaparanta-Solin, Merja, Solin, Olof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574958/
https://www.ncbi.nlm.nih.gov/pubmed/28083825
http://dx.doi.org/10.1007/s11307-016-1040-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574958/
https://www.ncbi.nlm.nih.gov/pubmed/28083825
http://dx.doi.org/10.1007/s11307-016-1040-z

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