Amyloid precursor protein drives down-regulation of mitochondrial oxidative phosphorylation independent of amyloid beta

Amyloid precursor protein (APP) and its extracellular domain, soluble APP alpha (sAPPα) play important physiological and neuroprotective roles. However, rare forms of familial Alzheimer’s disease are associated with mutations in APP that increase toxic amyloidogenic cleavage of APP and produce amylo...

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Detalles Bibliográficos
Autores principales: Lopez Sanchez, M. Isabel G., Waugh, Hayley S., Tsatsanis, Andrew, Wong, Bruce X., Crowston, Jonathan G., Duce, James A., Trounce, Ian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574989/
https://www.ncbi.nlm.nih.gov/pubmed/28852095
http://dx.doi.org/10.1038/s41598-017-10233-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574989/
https://www.ncbi.nlm.nih.gov/pubmed/28852095
http://dx.doi.org/10.1038/s41598-017-10233-0

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