Frequency-dependent drug screening using optogenetic stimulation of human iPSC-derived cardiomyocytes

Side effects on cardiac ion channels are one major reason for new drugs to fail during preclinical evaluation. Herein we propose a simple optogenetic screening tool measuring extracellular field potentials (FP) from paced cardiomyocytes to identify drug effects over the whole physiological heart ran...

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Detalles Bibliográficos
Autores principales: Lapp, Hendrik, Bruegmann, Tobias, Malan, Daniela, Friedrichs, Stephanie, Kilgus, Carsten, Heidsieck, Alexandra, Sasse, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575076/
https://www.ncbi.nlm.nih.gov/pubmed/28851973
http://dx.doi.org/10.1038/s41598-017-09760-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575076/
https://www.ncbi.nlm.nih.gov/pubmed/28851973
http://dx.doi.org/10.1038/s41598-017-09760-7

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