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Frequency-dependent drug screening using optogenetic stimulation of human iPSC-derived cardiomyocytes
Side effects on cardiac ion channels are one major reason for new drugs to fail during preclinical evaluation. Herein we propose a simple optogenetic screening tool measuring extracellular field potentials (FP) from paced cardiomyocytes to identify drug effects over the whole physiological heart ran...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575076/ https://www.ncbi.nlm.nih.gov/pubmed/28851973 http://dx.doi.org/10.1038/s41598-017-09760-7 |