Integrative Approach with Electrophysiological and Theoretical Methods Reveals a New Role of S4 Positively Charged Residues in PKD2L1 Channel Voltage-Sensing

Numerical model-based simulations provide important insights into ion channel gating when experimental limitations exist. Here, a novel strategy combining numerical simulations with patch clamp experiments was used to investigate the net positive charges in the putative transmembrane segment 4 (S4)...

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Detalles Bibliográficos
Autores principales: Numata, Tomohiro, Tsumoto, Kunichika, Yamada, Kazunori, Kurokawa, Tatsuki, Hirose, Shinichi, Nomura, Hideki, Kawano, Mitsuhiro, Kurachi, Yoshihisa, Inoue, Ryuji, Mori, Yasuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575081/
https://www.ncbi.nlm.nih.gov/pubmed/28852171
http://dx.doi.org/10.1038/s41598-017-10357-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575081/
https://www.ncbi.nlm.nih.gov/pubmed/28852171
http://dx.doi.org/10.1038/s41598-017-10357-3

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