Cargando…

Integrative Approach with Electrophysiological and Theoretical Methods Reveals a New Role of S4 Positively Charged Residues in PKD2L1 Channel Voltage-Sensing

Numerical model-based simulations provide important insights into ion channel gating when experimental limitations exist. Here, a novel strategy combining numerical simulations with patch clamp experiments was used to investigate the net positive charges in the putative transmembrane segment 4 (S4)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Numata, Tomohiro, Tsumoto, Kunichika, Yamada, Kazunori, Kurokawa, Tatsuki, Hirose, Shinichi, Nomura, Hideki, Kawano, Mitsuhiro, Kurachi, Yoshihisa, Inoue, Ryuji, Mori, Yasuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575081/ https://www.ncbi.nlm.nih.gov/pubmed/28852171 http://dx.doi.org/10.1038/s41598-017-10357-3

Ejemplares similares

HD Physiology Project—Japanese efforts to promote multilevel integrative systems biology and physiome research
por: Furutani, Kazuharu, et al.
Publicado: (2017)

Integrative and theoretical research on the architecture of a biological system and its disorder
por: Uchida, Shinichi, et al.
Publicado: (2019)

Hysteretic Dynamics of Multi-Stable Early Afterdepolarisations with Repolarisation Reserve Attenuation: A Potential Dynamical Mechanism for Cardiac Arrhythmias
por: Tsumoto, Kunichika, et al.
Publicado: (2017)

Ischemia-Related Subcellular Redistribution of Sodium Channels Enhances the Proarrhythmic Effect of Class I Antiarrhythmic Drugs: A Simulation Study
por: Tsumoto, Kunichika, et al.
Publicado: (2014)

Specific decreasing of Na(+) channel expression on the lateral membrane of cardiomyocytes causes fatal arrhythmias in Brugada syndrome
por: Tsumoto, Kunichika, et al.
Publicado: (2020)

Facilitation of I(Kr) current by some hERG channel blockers suppresses early afterdepolarizations
por: Furutani, Kazuharu, et al.
Publicado: (2019)

The response of PKD1L3 / PKD2L1 to acid stimuli is inhibited by capsaicin and its pungent analogs
por: Ishii, Sho, et al.
Publicado: (2012)

Novel HCN2 Mutation Contributes to Febrile Seizures by Shifting the Channel's Kinetics in a Temperature-Dependent Manner
por: Nakamura, Yuki, et al.
Publicado: (2013)

Electrophysiological Analysis of Antimicrobial Peptides in Diverse Species
por: Saigo, Naoki, et al.
Publicado: (2019)

Bifurcations and Proarrhythmic Behaviors in Cardiac Electrical Excitations
por: Tsumoto, Kunichika, et al.
Publicado: (2022)

Pkd1 and Pkd2 Are Required for Normal Placental Development
por: Garcia-Gonzalez, Miguel A., et al.
Publicado: (2010)

Integrated field, laboratory, and theoretical study of PKD spread in a Swiss prealpine river
por: Carraro, Luca, et al.
Publicado: (2017)

Structural determinants at the M2 muscarinic receptor modulate the RGS4-GIRK response to pilocarpine by impairment of the receptor voltage sensitivity
por: Chen, I-Shan, et al.
Publicado: (2017)

A potentially crucial role of the PKD1 C-terminal tail in renal prognosis
por: Higashihara, Eiji, et al.
Publicado: (2017)

Long α helices projecting from the membrane as the dimer interface in the voltage-gated H(+) channel
por: Fujiwara, Yuichiro, et al.
Publicado: (2014)

The asparagine 533 residue in the outer pore loop region of the mouse PKD2L1 channel is essential for its voltage‐dependent inactivation
por: Shimizu, Takahiro, et al.
Publicado: (2017)

High Resolution Melt analysis for mutation screening in PKD1 and PKD2
por: Bataille, Stanislas, et al.
Publicado: (2011)

p53 mutation regulates PKD genes and results in co-occurrence of PKD and tumorigenesis
por: Li, Haili, et al.
Publicado: (2019)

PKD1 and PKD2 mutations in Slovenian families with autosomal dominant polycystic kidney disease
por: Vouk, Katja, et al.
Publicado: (2006)

Modeling Light Adaptation in Circadian Clock: Prediction of the Response That Stabilizes Entrainment
por: Tsumoto, Kunichika, et al.
Publicado: (2011)

Polycystic Kidney Disease Caused by Bilineal Inheritance of Truncating PKD1 as Well as PKD2 Mutations
por: Losekoot, Monique, et al.
Publicado: (2020)

PKD1 and PKD2 mRNA cis-inhibition drives polycystic kidney disease progression
por: Lakhia, Ronak, et al.
Publicado: (2022)

Small Interactor of PKD2 (SIP), a novel PKD2-related single-pass transmembrane protein, is required for proteolytic processing and ciliary import of Chlamydomonas PKD2
por: Das, Poulomi, et al.
Publicado: (2023)

PKD1 Mutation Is a Biomarker for Autosomal Dominant Polycystic Kidney Disease
por: Kimura, Tomoki, et al.
Publicado: (2023)

Role of PKD2 in Rheotaxis in Dictyostelium
por: Lima, Wanessa C., et al.
Publicado: (2014)

Molecular diagnosis of an infant with TSC2/PKD1 contiguous gene syndrome
por: Osumi, Keita, et al.
Publicado: (2020)

Identification of novel PKD1 and PKD2 mutations in Korean patients with autosomal dominant polycystic kidney disease
por: Choi, Rihwa, et al.
Publicado: (2014)

PKD1 Compared With PKD2 Genotype and Cardiac Hospitalizations in the Halt Progression of Polycystic Kidney Disease Studies
por: Steele, Cortney, et al.
Publicado: (2021)

Identified eleven exon variants in PKD1 and PKD2 genes that altered RNA splicing by minigene assay
por: Liu, Xuyan, et al.
Publicado: (2023)

Dynamics of receptor-operated Ca(2+) currents through TRPC channels controlled via the PI(4,5)P(2)-PLC signaling pathway
por: Mori, Masayuki X., et al.
Publicado: (2015)

Identification of novel PKD1 and PKD2 mutations in a Chinese population with autosomal dominant polycystic kidney disease
por: Liu, Bei, et al.
Publicado: (2015)

Prediction of Renal Prognosis in Patients with Autosomal Dominant Polycystic Kidney Disease Using PKD1/PKD2 Mutations
por: Kataoka, Hiroshi, et al.
Publicado: (2020)

Structural basis for Ca(2+) activation of the heteromeric PKD1L3/PKD2L1 channel
por: Su, Qiang, et al.
Publicado: (2021)

Technical Evaluation: Identification of Pathogenic Mutations in PKD1 and PKD2 in Patients with Autosomal Dominant Polycystic Kidney Disease by Next-Generation Sequencing and Use of a Comprehensive New Classification System
por: Kinoshita, Moritoshi, et al.
Publicado: (2016)

Control-theoretic integration of stimulation and electrophysiology for cognitive enhancement
por: Singh, Matthew F., et al.
Publicado: (2022)

Design, Synthesis, and Biological Evaluation of PKD Inhibitors
por: George, Kara M., et al.
Publicado: (2011)

Correction: Role of PKD2 in Rheotaxis in Dictyostelium
Publicado: (2014)

Diagnosis of autosomal dominant polycystic kidney disease using efficient PKD1 and PKD2 targeted next-generation sequencing
por: Trujillano, Daniel, et al.
Publicado: (2014)

Corrigendum: Identification of novel PKD1 and PKD2 mutations in a Chinese population with autosomal dominant polycystic kidney disease
por: Liu, Bei, et al.
Publicado: (2016)

Deciphering Variability of PKD1 and PKD2 in an Italian Cohort of 643 Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD)
por: Carrera, Paola, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_nhbjhmesev2vjhnhopridtvipf