Cargando…
Semi-synthetic vNAR libraries screened against therapeutic antibodies primarily deliver anti-idiotypic binders
Anti-idiotypic binders which specifically recognize the variable region of monoclonal antibodies have proven to be robust tools for pharmacokinetic studies of antibody therapeutics and for the development of cancer vaccines. In the present investigation, we focused on the identification of anti-idio...
Autores principales: | Könning, Doreen, Rhiel, Laura, Empting, Martin, Grzeschik, Julius, Sellmann, Carolin, Schröter, Christian, Zielonka, Stefan, Dickgießer, Stephan, Pirzer, Thomas, Yanakieva, Desislava, Becker, Stefan, Kolmar, Harald |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575089/ https://www.ncbi.nlm.nih.gov/pubmed/28852148 http://dx.doi.org/10.1038/s41598-017-10513-9 |
Ejemplares similares
-
Structural insights and biomedical potential of IgNAR scaffolds from sharks
por: Zielonka, Stefan, et al.
Publicado: (2014) -
Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain
por: Burgess, Selena G., et al.
Publicado: (2016) -
Intraocular Penetration of a vNAR: In Vivo and In Vitro VEGF(165) Neutralization
por: Camacho-Villegas, Tanya A., et al.
Publicado: (2018) -
Specific Targeting of Lymphoma Cells Using Semisynthetic Anti-Idiotype Shark Antibodies
por: Macarrón Palacios, Arturo, et al.
Publicado: (2020) -
Synthetic libraries of shark vNAR domains with different cysteine numbers within the CDR3
por: Cabanillas-Bernal, Olivia, et al.
Publicado: (2019)