Peptide SS-31 upregulates frataxin expression and improves the quality of mitochondria: implications in the treatment of Friedreich ataxia

Friedreich ataxia is a progressive neurodegenerative disease caused by the expansion of GAA trinucleotide repeats within the first intron of the FXN gene, which encodes frataxin. The pathophysiology of the disease is thought to be derived from the decrease of Fe-S cluster biogenesis due to frataxin...

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Detalles Bibliográficos
Autores principales: Zhao, Hongting, Li, Huihui, Hao, Shuangying, Chen, Jiping, Wu, Jing, Song, Chuanhui, Zhang, Meng, Qiao, Tong, Li, Kuanyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575096/
https://www.ncbi.nlm.nih.gov/pubmed/28852135
http://dx.doi.org/10.1038/s41598-017-10320-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575096/
https://www.ncbi.nlm.nih.gov/pubmed/28852135
http://dx.doi.org/10.1038/s41598-017-10320-2

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