Poliovirus intrahost evolution is required to overcome tissue-specific innate immune responses

RNA viruses, such as poliovirus, have a great evolutionary capacity, allowing them to quickly adapt and overcome challenges encountered during infection. Here we show that poliovirus infection in immune-competent mice requires adaptation to tissue-specific innate immune microenvironments. The abilit...

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Detalles Bibliográficos
Autores principales: Xiao, Yinghong, Dolan, Patrick Timothy, Goldstein, Elizabeth Faul, Li, Min, Farkov, Mikhail, Brodsky, Leonid, Andino, Raul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575128/
https://www.ncbi.nlm.nih.gov/pubmed/28851882
http://dx.doi.org/10.1038/s41467-017-00354-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575128/
https://www.ncbi.nlm.nih.gov/pubmed/28851882
http://dx.doi.org/10.1038/s41467-017-00354-5

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