Production of Monoclonal Antibodies to Pathologic β-sheet Oligomeric Conformers in Neurodegenerative Diseases

We describe a novel approach to produce conformational monoclonal antibodies selected to specifically react with the β-sheet secondary structure of pathological oligomeric conformers, characteristic of many neurodegenerative diseases. Contrary to past and current efforts, we utilize a mammalian non-...

Descripción completa

Detalles Bibliográficos
Autores principales: Goñi, Fernando, Martá-Ariza, Mitchell, Peyser, Daniel, Herline, Krystal, Wisniewski, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575137/
https://www.ncbi.nlm.nih.gov/pubmed/28852189
http://dx.doi.org/10.1038/s41598-017-10393-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575137/
https://www.ncbi.nlm.nih.gov/pubmed/28852189
http://dx.doi.org/10.1038/s41598-017-10393-z

Ejemplares similares