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Production of Monoclonal Antibodies to Pathologic β-sheet Oligomeric Conformers in Neurodegenerative Diseases

We describe a novel approach to produce conformational monoclonal antibodies selected to specifically react with the β-sheet secondary structure of pathological oligomeric conformers, characteristic of many neurodegenerative diseases. Contrary to past and current efforts, we utilize a mammalian non-...

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Detalles Bibliográficos
Autores principales:	Goñi, Fernando, Martá-Ariza, Mitchell, Peyser, Daniel, Herline, Krystal, Wisniewski, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575137/ https://www.ncbi.nlm.nih.gov/pubmed/28852189 http://dx.doi.org/10.1038/s41598-017-10393-z

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