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Identification of butenolide regulatory system controlling secondary metabolism in Streptomyces albus J1074

A large majority of genome-encrypted chemical diversity in actinobacteria remains to be discovered, which is related to the low level of secondary metabolism genes expression. Here, we report the application of a reporter-guided screening strategy to activate cryptic polycyclic tetramate macrolactam...

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Detalles Bibliográficos
Autores principales: Ahmed, Yousra, Rebets, Yuriy, Tokovenko, Bogdan, Brötz, Elke, Luzhetskyy, Andriy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575351/
https://www.ncbi.nlm.nih.gov/pubmed/28852167
http://dx.doi.org/10.1038/s41598-017-10316-y