Structure‐Enabled Discovery of a Stapled Peptide Inhibitor to Target the Oncogenic Transcriptional Repressor TLE1

TLE1 is an oncogenic transcriptional co‐repressor that exerts its repressive effects through binding of transcription factors. Inhibition of this protein–protein interaction represents a putative cancer target, but no small‐molecule inhibitors have been published for this challenging interface. Here...

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Detalles Bibliográficos
Autores principales: McGrath, Sally, Tortorici, Marcello, Drouin, Ludovic, Solanki, Savade, Vidler, Lewis, Westwood, Isaac, Gimeson, Peter, Van Montfort, Rob, Hoelder, Swen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575474/
https://www.ncbi.nlm.nih.gov/pubmed/28326635
http://dx.doi.org/10.1002/chem.201700747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575474/
https://www.ncbi.nlm.nih.gov/pubmed/28326635
http://dx.doi.org/10.1002/chem.201700747

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