Liver microsomal lipid enhances the activity and redox coupling of colocalized cytochrome P450 reductase‐cytochrome P450 3A4 in nanodiscs

The haem‐containing mono‐oxygenase cytochrome P450 3A4 (CYP3A4) and its redox partner NADPH‐dependent cytochrome P450 oxidoreductase (CPR) are among the most important enzymes in human liver for metabolizing drugs and xenobiotic compounds. They are membrane‐bound in the endoplasmic reticulum (ER). H...

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Detalles Bibliográficos
Autores principales: Liu, Kang‐Cheng, Hughes, John M. X., Hay, Sam, Scrutton, Nigel S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575521/
https://www.ncbi.nlm.nih.gov/pubmed/28618157
http://dx.doi.org/10.1111/febs.14129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575521/
https://www.ncbi.nlm.nih.gov/pubmed/28618157
http://dx.doi.org/10.1111/febs.14129

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