Studying the Conformation of a Receptor Tyrosine Kinase in Solution by Inhibitor‐Based Spin Labeling

The synthesis of a spin label based on PD168393, a covalent inhibitor of a major anticancer drug target, the epidermal growth factor receptor (EGFR), is reported. The label facilitates the analysis of the EGFR structure in solution by pulsed electron paramagnetic resonance (EPR) spectroscopy. For va...

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Detalles Bibliográficos
Autores principales: Yin, Dongsheng M., Hannam, Jeffrey S., Schmitz, Anton, Schiemann, Olav, Hagelueken, Gregor, Famulok, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575716/
https://www.ncbi.nlm.nih.gov/pubmed/28628261
http://dx.doi.org/10.1002/anie.201703154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575716/
https://www.ncbi.nlm.nih.gov/pubmed/28628261
http://dx.doi.org/10.1002/anie.201703154

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