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Gene functioning and storage within a folded genome

In mammals, genomic DNA that is roughly 2 m long is folded to fit the size of the cell nucleus that has a diameter of about 10 μm. The folding of genomic DNA is mediated via assembly of DNA-protein complex, chromatin. In addition to the reduction of genomic DNA linear dimensions, the assembly of chr...

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Detalles Bibliográficos
Autores principales: Razin, Sergey V., Ulianov, Sergey V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575855/
https://www.ncbi.nlm.nih.gov/pubmed/28861108
http://dx.doi.org/10.1186/s11658-017-0050-4