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Gut Microbiota is critical for the induction of chemotherapy-induced pain
Chemotherapy-induced pain is a dose-limiting condition that affects 30% of patients undergoing chemotherapy. We found that the gut microbiota promotes the development of chemotherapy-induced mechanical hyperalgesia. Oxaliplatin-induced mechnical hyperalgesia was reduced in germ-free mice and in thos...
| Autores principales: | , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575957/ https://www.ncbi.nlm.nih.gov/pubmed/28714953 http://dx.doi.org/10.1038/nn.4606 |
| _version_ | 1783260130379300864 |
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| author | Shen, Shiqian Lim, Grewo You, Zerong Ding, Weihua Huang, Peigen Ran, Chongzhao Doheny, Jason Caravan, Peter Tate, Samuel Hu, Kun Kim, Hyangin McCabe, Michael Huang, Bo Xie, Zhongcong Kwon, Douglas Chen, Lucy Mao, Jianren |
| author_facet | Shen, Shiqian Lim, Grewo You, Zerong Ding, Weihua Huang, Peigen Ran, Chongzhao Doheny, Jason Caravan, Peter Tate, Samuel Hu, Kun Kim, Hyangin McCabe, Michael Huang, Bo Xie, Zhongcong Kwon, Douglas Chen, Lucy Mao, Jianren |
| author_sort | Shen, Shiqian |
| collection | PubMed |
| description | Chemotherapy-induced pain is a dose-limiting condition that affects 30% of patients undergoing chemotherapy. We found that the gut microbiota promotes the development of chemotherapy-induced mechanical hyperalgesia. Oxaliplatin-induced mechnical hyperalgesia was reduced in germ-free mice and in those mice pretreated with antibiotics. Restoration of the microbiota of germ-free mice abrogated this protection. These effects appear to be mediated, in part, by TLR4 expressed on hematopoietic cells, including macrophages. |
| format | Online Article Text |
| id | pubmed-5575957 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-55759572018-01-17 Gut Microbiota is critical for the induction of chemotherapy-induced pain Shen, Shiqian Lim, Grewo You, Zerong Ding, Weihua Huang, Peigen Ran, Chongzhao Doheny, Jason Caravan, Peter Tate, Samuel Hu, Kun Kim, Hyangin McCabe, Michael Huang, Bo Xie, Zhongcong Kwon, Douglas Chen, Lucy Mao, Jianren Nat Neurosci Article Chemotherapy-induced pain is a dose-limiting condition that affects 30% of patients undergoing chemotherapy. We found that the gut microbiota promotes the development of chemotherapy-induced mechanical hyperalgesia. Oxaliplatin-induced mechnical hyperalgesia was reduced in germ-free mice and in those mice pretreated with antibiotics. Restoration of the microbiota of germ-free mice abrogated this protection. These effects appear to be mediated, in part, by TLR4 expressed on hematopoietic cells, including macrophages. 2017-07-17 2017-09 /pmc/articles/PMC5575957/ /pubmed/28714953 http://dx.doi.org/10.1038/nn.4606 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Shen, Shiqian Lim, Grewo You, Zerong Ding, Weihua Huang, Peigen Ran, Chongzhao Doheny, Jason Caravan, Peter Tate, Samuel Hu, Kun Kim, Hyangin McCabe, Michael Huang, Bo Xie, Zhongcong Kwon, Douglas Chen, Lucy Mao, Jianren Gut Microbiota is critical for the induction of chemotherapy-induced pain |
| title | Gut Microbiota is critical for the induction of chemotherapy-induced pain |
| title_full | Gut Microbiota is critical for the induction of chemotherapy-induced pain |
| title_fullStr | Gut Microbiota is critical for the induction of chemotherapy-induced pain |
| title_full_unstemmed | Gut Microbiota is critical for the induction of chemotherapy-induced pain |
| title_short | Gut Microbiota is critical for the induction of chemotherapy-induced pain |
| title_sort | gut microbiota is critical for the induction of chemotherapy-induced pain |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575957/ https://www.ncbi.nlm.nih.gov/pubmed/28714953 http://dx.doi.org/10.1038/nn.4606 |
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