Enhanced exosome secretion in Down syndrome brain - a protective mechanism to alleviate neuronal endosomal abnormalities

A dysfunctional endosomal pathway and abnormally enlarged early endosomes in neurons are an early characteristic of Down syndrome (DS) and Alzheimer’s disease (AD). We have hypothesized that endosomal material can be released by endosomal multivesicular bodies (MVBs) into the extracellular space via...

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Detalles Bibliográficos
Autores principales: Gauthier, Sébastien A., Pérez-González, Rocío, Sharma, Ajay, Huang, Fang-Ke, Alldred, Melissa J., Pawlik, Monika, Kaur, Gurjinder, Ginsberg, Stephen D., Neubert, Thomas A., Levy, Efrat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576289/
https://www.ncbi.nlm.nih.gov/pubmed/28851452
http://dx.doi.org/10.1186/s40478-017-0466-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576289/
https://www.ncbi.nlm.nih.gov/pubmed/28851452
http://dx.doi.org/10.1186/s40478-017-0466-0

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