Tumoral LINE-1 hypomethylation is associated with poor survival of patients with intrahepatic cholangiocarcinoma

BACKGROUND: DNA methylation changes occurring in cancer cells are featured with both promoter CpG island hypermethylation and diffuse genomic hypomethylation. Long interspersed element-1 (LINE-1) is repeated in an interspersed manner with an estimated 500,000 copies per genome. LINE-1 has its CpG si...

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Detalles Bibliográficos
Autores principales: Jeong, Seorin, Lee, Kyoungbun, Wen, Xianyu, Kim, Younghoon, Cho, Nam-Yun, Jang, Ja-June, Kang, Gyeong Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576385/
https://www.ncbi.nlm.nih.gov/pubmed/28851390
http://dx.doi.org/10.1186/s12885-017-3595-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576385/
https://www.ncbi.nlm.nih.gov/pubmed/28851390
http://dx.doi.org/10.1186/s12885-017-3595-8

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