Gemcitabine treatment induces endoplasmic reticular (ER) stress and subsequently upregulates urokinase plasminogen activator (uPA) to block mitochondrial-dependent apoptosis in Panc-1 cancer stem-like cells (CSCs)

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor survival rates. The presence of cancer stem-like cells (CSCs) is believed to be among the underlying reasons for the aggressiveness of PDAC, which contributes to chemoresistance and recurrence. However, the mechani...

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Detalles Bibliográficos
Autores principales: Wang, Li, Zhang, Yi, Wang, Weiguo, Zhu, Yunjie, Chen, Yang, Tian, Bole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576696/
https://www.ncbi.nlm.nih.gov/pubmed/28854261
http://dx.doi.org/10.1371/journal.pone.0184110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576696/
https://www.ncbi.nlm.nih.gov/pubmed/28854261
http://dx.doi.org/10.1371/journal.pone.0184110

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