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The Calcineurin-FoxO-MuRF1 signaling pathway regulates myofibril integrity in cardiomyocytes
Altered Ca(2+) handling is often present in diseased hearts undergoing structural remodeling and functional deterioration. However, whether Ca(2+) directly regulates sarcomere structure has remained elusive. Using a zebrafish ncx1 mutant, we explored the impacts of impaired Ca(2+) homeostasis on myo...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576919/ https://www.ncbi.nlm.nih.gov/pubmed/28826496 http://dx.doi.org/10.7554/eLife.27955 |