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The Calcineurin-FoxO-MuRF1 signaling pathway regulates myofibril integrity in cardiomyocytes

Altered Ca(2+) handling is often present in diseased hearts undergoing structural remodeling and functional deterioration. However, whether Ca(2+) directly regulates sarcomere structure has remained elusive. Using a zebrafish ncx1 mutant, we explored the impacts of impaired Ca(2+) homeostasis on myo...

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Detalles Bibliográficos
Autores principales:	Shimizu, Hirohito, Langenbacher, Adam D, Huang, Jie, Wang, Kevin, Otto, Georg, Geisler, Robert, Wang, Yibin, Chen, Jau-Nian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576919/ https://www.ncbi.nlm.nih.gov/pubmed/28826496 http://dx.doi.org/10.7554/eLife.27955

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