A Novel IMP1 Inhibitor, BTYNB, Targets c-Myc and Inhibits Melanoma and Ovarian Cancer Cell Proliferation

The oncofetal mRNA-binding protein, IMP1 or insulin-like growth factor-2 mRNA-binding protein 2 (IGF2BP1), binds to and stabilizes c-Myc, β-TrCP1, and other oncogenic mRNAs, leading to increased expression of the proteins encoded by its target mRNAs. IMP1 is frequently overexpressed in cancer and is...

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Detalles Bibliográficos
Autores principales: Mahapatra, Lily, Andruska, Neal, Mao, Chengjian, Le, Jeremy, Shapiro, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2017
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576976/
https://www.ncbi.nlm.nih.gov/pubmed/28846937
http://dx.doi.org/10.1016/j.tranon.2017.07.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576976/
https://www.ncbi.nlm.nih.gov/pubmed/28846937
http://dx.doi.org/10.1016/j.tranon.2017.07.008

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