XWL-1-48 exerts antitumor activity via targeting topoisomerase II and enhancing degradation of Mdm2 in human hepatocellular carcinoma

A novel podophyllotoxin derivative, XWL-1-48, was synthesized as an oral topoisomerase II inhibitor. kDNA decatenation assay indicated that XWL-1-48 significantly inhibited topoisomerase II activity in a concentration-dependent manner. Moreover, the cytotoxicity of XWL-1-48 is more potent than its c...

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Detalles Bibliográficos
Autores principales: Wang, Yajie, Sun, Hua, Xiao, Zhiyan, Zhang, Dan, Bao, Xiuqi, Wei, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577045/
https://www.ncbi.nlm.nih.gov/pubmed/28855652
http://dx.doi.org/10.1038/s41598-017-10577-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577045/
https://www.ncbi.nlm.nih.gov/pubmed/28855652
http://dx.doi.org/10.1038/s41598-017-10577-7

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