Prostaglandin E1 Attenuates Pulmonary Artery Remodeling by Activating Phosphorylation of CREB and the PTEN Signaling Pathway

The depletion of cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) and phosphatase and tensin homolog (PTEN) is the critical mediator of pulmonary arterial hypertension (PAH). We hypothesized that the activation of phosphorylated CREB (pCREB) and PTEN could inhibit the AK...

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Detalles Bibliográficos
Autores principales: Lai, Ying-Ju, Hsu, Hsao-Hsun, Chang, Gwo-Jyh, Lin, Shu-Hui, Chen, Wei-Jan, Huang, Chung-Chi, Pang, Jong-Hwei S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577102/
https://www.ncbi.nlm.nih.gov/pubmed/28855544
http://dx.doi.org/10.1038/s41598-017-09707-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577102/
https://www.ncbi.nlm.nih.gov/pubmed/28855544
http://dx.doi.org/10.1038/s41598-017-09707-y

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