Pseudo-acetylation of multiple sites on human Tau proteins alters Tau phosphorylation and microtubule binding, and ameliorates amyloid beta toxicity

Tau is a microtubule-associated protein that is highly soluble and natively unfolded. Its dysfunction is involved in the pathogenesis of several neurodegenerative disorders including Alzheimer’s disease (AD), where it aggregates within neurons. Deciphering the physiological and pathogenic roles of h...

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Detalles Bibliográficos
Autores principales: Gorsky, Marianna Karina, Burnouf, Sylvie, Sofola-Adesakin, Oyinkan, Dols, Jacqueline, Augustin, Hrvoje, Weigelt, Carina Marianne, Grönke, Sebastian, Partridge, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577152/
https://www.ncbi.nlm.nih.gov/pubmed/28855586
http://dx.doi.org/10.1038/s41598-017-10225-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577152/
https://www.ncbi.nlm.nih.gov/pubmed/28855586
http://dx.doi.org/10.1038/s41598-017-10225-0

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