Both p62/SQSTM1-HDAC6-dependent autophagy and the aggresome pathway mediate CDK1 degradation in human breast cancer

Cyclin-dependent kinase 1 (CDK1) is the central mammalian regulator of cell proliferation and a promising therapeutic target for breast cancer. In fact, CDK1 inhibition downregulates survival and induces apoptosis. Due to its essential role, CDK1 expression and activity are strictly controlled at va...

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Detalles Bibliográficos
Autores principales: Galindo-Moreno, María, Giráldez, Servando, Sáez, Carmen, Japón, Miguel Á., Tortolero, Maria, Romero, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577189/
https://www.ncbi.nlm.nih.gov/pubmed/28855742
http://dx.doi.org/10.1038/s41598-017-10506-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577189/
https://www.ncbi.nlm.nih.gov/pubmed/28855742
http://dx.doi.org/10.1038/s41598-017-10506-8

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