Dysfunction of the circadian transcriptional factor CLOCK in mice resists chemical carcinogen-induced tumorigenesis

The chronic disruption of circadian rhythms has been implicated in the risk of cancer development in humans and laboratory animals. The gene product CLOCK is a core molecular component of the circadian oscillator, so that mice with a mutated Clock gene (Clk/Clk) exhibit abnormal rhythms in various p...

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Detalles Bibliográficos
Autores principales: Hashikawa, Ken-ichi, Katamune, Chiharu, Kusunose, Naoki, Matsunaga, Naoya, Koyanagi, Satoru, Ohdo, Shigehiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577256/
https://www.ncbi.nlm.nih.gov/pubmed/28855649
http://dx.doi.org/10.1038/s41598-017-10599-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577256/
https://www.ncbi.nlm.nih.gov/pubmed/28855649
http://dx.doi.org/10.1038/s41598-017-10599-1

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