Cargando…

Dysfunction of the circadian transcriptional factor CLOCK in mice resists chemical carcinogen-induced tumorigenesis

The chronic disruption of circadian rhythms has been implicated in the risk of cancer development in humans and laboratory animals. The gene product CLOCK is a core molecular component of the circadian oscillator, so that mice with a mutated Clock gene (Clk/Clk) exhibit abnormal rhythms in various p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hashikawa, Ken-ichi, Katamune, Chiharu, Kusunose, Naoki, Matsunaga, Naoya, Koyanagi, Satoru, Ohdo, Shigehiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577256/ https://www.ncbi.nlm.nih.gov/pubmed/28855649 http://dx.doi.org/10.1038/s41598-017-10599-1

Ejemplares similares

Circadian clock component PERIOD2 regulates diurnal expression of Na(+)/H(+) exchanger regulatory factor-1 and its scaffolding function
por: Tsurudome, Yuya, et al.
Publicado: (2018)

The intrinsic microglial molecular clock controls synaptic strength via the circadian expression of cathepsin S
por: Hayashi, Yoshinori, et al.
Publicado: (2013)

Post-transcriptional repression of circadian component CLOCK regulates cancer-stemness in murine breast cancer cells
por: Ogino, Takashi, et al.
Publicado: (2021)

RNA editing enzyme ADAR1 governs the circadian expression of P-glycoprotein in human renal cells by regulating alternative splicing of the ABCB1 gene
por: Omata, Yuji, et al.
Publicado: (2021)

Molecular basis for the dosing time-dependency of anti-allodynic effects of gabapentin in a mouse model of neuropathic pain
por: Kusunose, Naoki, et al.
Publicado: (2010)

RNA editing enzyme ADAR1 controls miR-381-3p-mediated expression of multidrug resistance protein MRP4 via regulation of circRNA in human renal cells
por: Omata, Yuji, et al.
Publicado: (2022)

Diurnal Expression of PD-1 on Tumor-Associated Macrophages Underlies the Dosing Time-Dependent Antitumor Effects of the PD-1/PD-L1 Inhibitor BMS-1 in B16/BL6 Melanoma-Bearing Mice
por: Tsuruta, Akito, et al.
Publicado: (2022)

Alteration of circadian machinery in monocytes underlies chronic kidney disease-associated cardiac inflammation and fibrosis
por: Yoshida, Yuya, et al.
Publicado: (2021)

Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia
por: Koyanagi, Satoru, et al.
Publicado: (2016)

Diurnal expression of MRP4 in bone marrow cells underlies the dosing-time dependent changes in the oxaliplatin-induced myelotoxicity
por: Kato, Mizuki, et al.
Publicado: (2020)

Opposite Carcinogenic Effects of Circadian Clock Gene BMAL1
por: Korkmaz, Tuba, et al.
Publicado: (2018)

Potential Effect of the Circadian Clock on Erectile Dysfunction
por: Li, Tao, et al.
Publicado: (2022)

Deregulation of the circadian clock constitutes a significant factor in tumorigenesis: a clockwork cancer. Part I: clocks and clocking machinery
por: Uth, Kristin, et al.
Publicado: (2014)

Dysregulation of Circadian Clock Genes as Significant Clinic Factor in the Tumorigenesis of Hepatocellular Carcinoma
por: Liang, Youfang, et al.
Publicado: (2021)

Roles of Neuropeptides, VIP and AVP, in the Mammalian Central Circadian Clock
por: Ono, Daisuke, et al.
Publicado: (2021)

Corrigendum: Roles of Neuropeptides, VIP and AVP, in the Mammalian Central Circadian Clock
por: Ono, Daisuke, et al.
Publicado: (2021)

Macrophage Meets the Circadian Clock: Implication of the Circadian Clock in the Role of Macrophages in Acute Lower Respiratory Tract Infection
por: Shirato, Ken, et al.
Publicado: (2022)

Ozagrel hydrochloride, a selective thromboxane A(2) synthase inhibitor, alleviates liver injury induced by acetaminophen overdose in mice
por: Tomishima, Yoshiro, et al.
Publicado: (2013)

The circadian clock in mammals
por: Zordan, M. A., et al.
Publicado: (2005)

The circadian clock in mammals
por: Zordan, Mauro, et al.
Publicado: (2000)

Circadian Clocks and Pregnancy
por: Olcese, James
Publicado: (2014)

Neurodegeneration and the Circadian Clock
por: Hood, Suzanne, et al.
Publicado: (2017)

The Circadian Clock in Lepidoptera
por: Brady, Daniel, et al.
Publicado: (2021)

Circadian Clock and Nutrition
por: Lewandowski, Marian H.
Publicado: (2023)

Circadian and ultradian rhythms of clock gene expression in the suprachiasmatic nucleus of freely moving mice
por: Ono, Daisuke, et al.
Publicado: (2015)

Green-sensitive opsin is the photoreceptor for photic entrainment of an insect circadian clock
por: Komada, Sayaka, et al.
Publicado: (2015)

Role of Aryl Hydrocarbon Receptor in Circadian Clock Disruption and Metabolic Dysfunction
por: Jaeger, Cassie, et al.
Publicado: (2016)

Miscellaneous Chemical Carcinogens: Chemical Constitution and Carcinogenic Activity
por: Badger, G. M.
Publicado: (1956)

Cinnamic acid shortens the period of the circadian clock in mice
por: Oishi, Katsutaka, et al.
Publicado: (2017)

Physiological links of circadian clock and biological clock of aging
por: Liu, Fang, et al.
Publicado: (2017)

The Kidney Clock Contributes to Timekeeping by the Master Circadian Clock
por: Myung, Jihwan, et al.
Publicado: (2019)

Enhancement of NAD(+)-dependent SIRT1 deacetylase activity by methylselenocysteine resets the circadian clock in carcinogen-treated mammary epithelial cells
por: Fang, Mingzhu, et al.
Publicado: (2015)

Oxidative Stress in the Carcinogenicity of Chemical Carcinogens
por: Kakehashi, Anna, et al.
Publicado: (2013)

Identification of circadian clock modulators from existing drugs
por: Tamai, T Katherine, et al.
Publicado: (2018)

The Circadian Clock, Reward, and Memory
por: Albrecht, Urs
Publicado: (2011)

The circadian clock goes genomic
por: Staiger, Dorothee, et al.
Publicado: (2013)

Circadian Clocks, Stress, and Immunity
por: Dumbell, Rebecca, et al.
Publicado: (2016)

Circadian Clock, Cancer, and Chemotherapy
por: Sancar, Aziz, et al.
Publicado: (2014)

Circadian clocks and breast cancer
por: Blakeman, Victoria, et al.
Publicado: (2016)

Circadian clock and oral cancer
por: Nirvani, Minou, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_f78t8f7586s50l3nqp0ir91gm1