Expression of IL-33 in ocular surface epithelium induces atopic keratoconjunctivitis with activation of group 2 innate lymphoid cells in mice

In a transgenic mouse line hK14mIL33tg, with the expression of interleukin-33 (IL-33) driven by a keratin 14 promoter, keratoconjunctivitis developed spontaneously between 18 and 22 weeks of age under specific-pathogen-free conditions. These mice showed blepharitis and corneal impairments, and the h...

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Detalles Bibliográficos
Autores principales: Imai, Yasutomo, Hosotani, Yuka, Ishikawa, Hiroto, Yasuda, Koubun, Nagai, Makoto, Jitsukawa, Orie, Gomi, Fumi, Nakanishi, Kenji, Yoshimoto, Tomohiro, Nakamura, Takahiro, Yamanishi, Kiyofumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577277/
https://www.ncbi.nlm.nih.gov/pubmed/28855579
http://dx.doi.org/10.1038/s41598-017-10227-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577277/
https://www.ncbi.nlm.nih.gov/pubmed/28855579
http://dx.doi.org/10.1038/s41598-017-10227-y

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