Oxidation of phosphorothioate DNA modifications leads to lethal genomic instability

Genomic modification with sulfur as phosphorothioate (PT) is widespread among prokaryotes, including human pathogens. Apart from its physiological functions, the redox and nucleophilic properties of PT sulfur suggest effects on bacterial fitness in stressful environments. Here we show that PTs are d...

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Detalles Bibliográficos
Autores principales: Kellner, Stefanie, DeMott, Michael S., Cheng, Ching Pin, Russell, Brandon, Cao, Bo, You, Delin, Dedon, Peter C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577368/
https://www.ncbi.nlm.nih.gov/pubmed/28604692
http://dx.doi.org/10.1038/nchembio.2407

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577368/
https://www.ncbi.nlm.nih.gov/pubmed/28604692
http://dx.doi.org/10.1038/nchembio.2407

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