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Genetic Analysis in UK Biobank Links Insulin Resistance and Transendothelial Migration Pathways to Coronary Artery Disease
UK Biobank is among the world’s largest repositories for phenotypic and genotypic information in individuals of European ancestry(1). We performed a genome-wide association study in UK Biobank testing ~9 million DNA sequence variants for association with coronary artery disease (4,831 cases; 115,455...
| Autores principales: | , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577383/ https://www.ncbi.nlm.nih.gov/pubmed/28714974 http://dx.doi.org/10.1038/ng.3914 |
| _version_ | 1783260346548486144 |
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| author | Klarin, Derek Zhu, Qiuyu Martin Emdin, Connor A. Chaffin, Mark Horner, Steven McMillan, Brian J. Leed, Alison Weale, Michael E. Spencer, Chris C. A. Aguet, François Segrè, Ayellet V. Ardlie, Kristin G. Khera, Amit V. Kaushik, Virendar K. Natarajan, Pradeep Consortium, CARDIoGRAMplusC4D Kathiresan, Sekar |
| author_facet | Klarin, Derek Zhu, Qiuyu Martin Emdin, Connor A. Chaffin, Mark Horner, Steven McMillan, Brian J. Leed, Alison Weale, Michael E. Spencer, Chris C. A. Aguet, François Segrè, Ayellet V. Ardlie, Kristin G. Khera, Amit V. Kaushik, Virendar K. Natarajan, Pradeep Consortium, CARDIoGRAMplusC4D Kathiresan, Sekar |
| author_sort | Klarin, Derek |
| collection | PubMed |
| description | UK Biobank is among the world’s largest repositories for phenotypic and genotypic information in individuals of European ancestry(1). We performed a genome-wide association study in UK Biobank testing ~9 million DNA sequence variants for association with coronary artery disease (4,831 cases; 115,455 controls) and carried out meta-analysis with previously published results. We identified fifteen novel loci, bringing the total number of coronary artery disease-associated loci to 95. Phenome-wide association scanning revealed that CCDC92 likely affects coronary artery disease through insulin resistance pathways whereas experimental analysis suggests that ARHGEF26 impacts the transendothelial migration of leukocytes. |
| format | Online Article Text |
| id | pubmed-5577383 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-55773832018-01-17 Genetic Analysis in UK Biobank Links Insulin Resistance and Transendothelial Migration Pathways to Coronary Artery Disease Klarin, Derek Zhu, Qiuyu Martin Emdin, Connor A. Chaffin, Mark Horner, Steven McMillan, Brian J. Leed, Alison Weale, Michael E. Spencer, Chris C. A. Aguet, François Segrè, Ayellet V. Ardlie, Kristin G. Khera, Amit V. Kaushik, Virendar K. Natarajan, Pradeep Consortium, CARDIoGRAMplusC4D Kathiresan, Sekar Nat Genet Article UK Biobank is among the world’s largest repositories for phenotypic and genotypic information in individuals of European ancestry(1). We performed a genome-wide association study in UK Biobank testing ~9 million DNA sequence variants for association with coronary artery disease (4,831 cases; 115,455 controls) and carried out meta-analysis with previously published results. We identified fifteen novel loci, bringing the total number of coronary artery disease-associated loci to 95. Phenome-wide association scanning revealed that CCDC92 likely affects coronary artery disease through insulin resistance pathways whereas experimental analysis suggests that ARHGEF26 impacts the transendothelial migration of leukocytes. 2017-07-17 2017-09 /pmc/articles/PMC5577383/ /pubmed/28714974 http://dx.doi.org/10.1038/ng.3914 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Klarin, Derek Zhu, Qiuyu Martin Emdin, Connor A. Chaffin, Mark Horner, Steven McMillan, Brian J. Leed, Alison Weale, Michael E. Spencer, Chris C. A. Aguet, François Segrè, Ayellet V. Ardlie, Kristin G. Khera, Amit V. Kaushik, Virendar K. Natarajan, Pradeep Consortium, CARDIoGRAMplusC4D Kathiresan, Sekar Genetic Analysis in UK Biobank Links Insulin Resistance and Transendothelial Migration Pathways to Coronary Artery Disease |
| title | Genetic Analysis in UK Biobank Links Insulin Resistance and Transendothelial Migration Pathways to Coronary Artery Disease |
| title_full | Genetic Analysis in UK Biobank Links Insulin Resistance and Transendothelial Migration Pathways to Coronary Artery Disease |
| title_fullStr | Genetic Analysis in UK Biobank Links Insulin Resistance and Transendothelial Migration Pathways to Coronary Artery Disease |
| title_full_unstemmed | Genetic Analysis in UK Biobank Links Insulin Resistance and Transendothelial Migration Pathways to Coronary Artery Disease |
| title_short | Genetic Analysis in UK Biobank Links Insulin Resistance and Transendothelial Migration Pathways to Coronary Artery Disease |
| title_sort | genetic analysis in uk biobank links insulin resistance and transendothelial migration pathways to coronary artery disease |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577383/ https://www.ncbi.nlm.nih.gov/pubmed/28714974 http://dx.doi.org/10.1038/ng.3914 |
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