Peptide‐Directed Binding for the Discovery of Modulators of α‐Helix‐Mediated Protein–Protein Interactions: Proof‐of‐Concept Studies with the Apoptosis Regulator Mcl‐1

Targeting PPIs with small molecules can be challenging owing to large, hydrophobic binding surfaces. Herein, we describe a strategy that exploits selective α‐helical PPIs, transferring these characteristics to small molecules. The proof of concept is demonstrated with the apoptosis regulator Mcl‐1,...

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Detalles Bibliográficos
Autores principales: Beekman, Andrew Michael, O'Connell, Maria Anne, Howell, Lesley Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577515/
https://www.ncbi.nlm.nih.gov/pubmed/28670766
http://dx.doi.org/10.1002/anie.201705008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577515/
https://www.ncbi.nlm.nih.gov/pubmed/28670766
http://dx.doi.org/10.1002/anie.201705008

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