Lengths of the C-Terminus and Interconnecting Loops Impact Stability of Spider-Derived Gating Modifier Toxins

Spider gating modifier toxins (GMTs) are potent modulators of voltage-gated ion channels and have thus attracted attention as drug leads for several pathophysiological conditions. GMTs contain three disulfide bonds organized in an inhibitory cystine knot, which putatively confers them with high stab...

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Detalles Bibliográficos
Autores principales: Agwa, Akello J., Huang, Yen-Hua, Craik, David J., Henriques, Sónia T., Schroeder, Christina I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577582/
https://www.ncbi.nlm.nih.gov/pubmed/28805686
http://dx.doi.org/10.3390/toxins9080248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577582/
https://www.ncbi.nlm.nih.gov/pubmed/28805686
http://dx.doi.org/10.3390/toxins9080248

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