Chemical Identity of Interaction of Protein with Reactive Metabolite of Diosbulbin B In Vitro and In Vivo

Diosbulbin B (DIOB), a hepatotoxic furan-containing compound, is a primary ingredient in Dioscorea bulbifera L., a common herbal medicine. Metabolic activation is required for DIOB-induced liver injury. Protein covalent binding of an electrophilic reactive intermediate of DIOB is considered to be on...

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Detalles Bibliográficos
Autores principales: Wang, Kai, Lin, Dongju, Guo, Xiucai, Huang, Wenlin, Zheng, Jiang, Peng, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577583/
https://www.ncbi.nlm.nih.gov/pubmed/28805726
http://dx.doi.org/10.3390/toxins9080249

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577583/
https://www.ncbi.nlm.nih.gov/pubmed/28805726
http://dx.doi.org/10.3390/toxins9080249

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