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Ruxolitinib/nilotinib cotreatment inhibits leukemia-propagating cells in Philadelphia chromosome-positive ALL

BACKGROUND: As one of the major treatment obstacles in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+)ALL), relapse of Ph(+)ALL may result from the persistence of leukemia-propagating cells (LPCs). Research using a xenograft mouse assay recently determined that LPCs were enriche...

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Detalles Bibliográficos
Autores principales: Kong, Yuan, Wu, Yi-Lin, Song, Yang, Shi, Min-Min, Cao, Xie-Na, Zhao, Hong-Yan, Qin, Ya-Zhen, Lai, Yue-Yun, Jiang, Hao, Jiang, Qian, Huang, Xiao-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577751/
https://www.ncbi.nlm.nih.gov/pubmed/28854975
http://dx.doi.org/10.1186/s12967-017-1286-5