Clinical implications of neoepitope landscapes for adult and pediatric cancers

Many immunotherapies rely on the presence of neoepitopes derived from somatic mutations that lead to altered peptide sequences. Several studies have now analyzed the neoepitope landscape of different cancer subtypes, predominantly for adult samples, which tend to feature significantly higher mutatio...

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Autores principales: Feng, Yang-Yang, Griffith, Obi L., Griffith, Malachi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577778/
https://www.ncbi.nlm.nih.gov/pubmed/28854952
http://dx.doi.org/10.1186/s13073-017-0470-9
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author Feng, Yang-Yang
Griffith, Obi L.
Griffith, Malachi
author_facet Feng, Yang-Yang
Griffith, Obi L.
Griffith, Malachi
author_sort Feng, Yang-Yang
collection PubMed
description Many immunotherapies rely on the presence of neoepitopes derived from somatic mutations that lead to altered peptide sequences. Several studies have now analyzed the neoepitope landscape of different cancer subtypes, predominantly for adult samples, which tend to feature significantly higher mutational burden. However, a new report publishing the first comprehensive analysis of the pediatric neoepitope landscape suggests that immunotherapies could also hold promise for pediatric cancers. See related research article 10.1186/s13073-017-0468-3
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spelling pubmed-55777782017-08-31 Clinical implications of neoepitope landscapes for adult and pediatric cancers Feng, Yang-Yang Griffith, Obi L. Griffith, Malachi Genome Med Research Highlight Many immunotherapies rely on the presence of neoepitopes derived from somatic mutations that lead to altered peptide sequences. Several studies have now analyzed the neoepitope landscape of different cancer subtypes, predominantly for adult samples, which tend to feature significantly higher mutational burden. However, a new report publishing the first comprehensive analysis of the pediatric neoepitope landscape suggests that immunotherapies could also hold promise for pediatric cancers. See related research article 10.1186/s13073-017-0468-3 BioMed Central 2017-08-31 /pmc/articles/PMC5577778/ /pubmed/28854952 http://dx.doi.org/10.1186/s13073-017-0470-9 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Highlight
Feng, Yang-Yang
Griffith, Obi L.
Griffith, Malachi
Clinical implications of neoepitope landscapes for adult and pediatric cancers
title Clinical implications of neoepitope landscapes for adult and pediatric cancers
title_full Clinical implications of neoepitope landscapes for adult and pediatric cancers
title_fullStr Clinical implications of neoepitope landscapes for adult and pediatric cancers
title_full_unstemmed Clinical implications of neoepitope landscapes for adult and pediatric cancers
title_short Clinical implications of neoepitope landscapes for adult and pediatric cancers
title_sort clinical implications of neoepitope landscapes for adult and pediatric cancers
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577778/
https://www.ncbi.nlm.nih.gov/pubmed/28854952
http://dx.doi.org/10.1186/s13073-017-0470-9
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