Structure and topology around the cleavage site regulate post-translational cleavage of the HIV-1 gp160 signal peptide

Like all other secretory proteins, the HIV-1 envelope glycoprotein gp160 is targeted to the endoplasmic reticulum (ER) by its signal peptide during synthesis. Proper gp160 folding in the ER requires core glycosylation, disulfide-bond formation and proline isomerization. Signal-peptide cleavage occur...

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Detalles Bibliográficos
Autores principales: Snapp, Erik Lee, McCaul, Nicholas, Quandte, Matthias, Cabartova, Zuzana, Bontjer, Ilja, Källgren, Carolina, Nilsson, IngMarie, Land, Aafke, von Heijne, Gunnar, Sanders, Rogier W, Braakman, Ineke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577925/
https://www.ncbi.nlm.nih.gov/pubmed/28753126
http://dx.doi.org/10.7554/eLife.26067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577925/
https://www.ncbi.nlm.nih.gov/pubmed/28753126
http://dx.doi.org/10.7554/eLife.26067

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