Cargando…

Structure and topology around the cleavage site regulate post-translational cleavage of the HIV-1 gp160 signal peptide

Like all other secretory proteins, the HIV-1 envelope glycoprotein gp160 is targeted to the endoplasmic reticulum (ER) by its signal peptide during synthesis. Proper gp160 folding in the ER requires core glycosylation, disulfide-bond formation and proline isomerization. Signal-peptide cleavage occur...

Descripción completa

Detalles Bibliográficos
Autores principales:	Snapp, Erik Lee, McCaul, Nicholas, Quandte, Matthias, Cabartova, Zuzana, Bontjer, Ilja, Källgren, Carolina, Nilsson, IngMarie, Land, Aafke, von Heijne, Gunnar, Sanders, Rogier W, Braakman, Ineke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577925/ https://www.ncbi.nlm.nih.gov/pubmed/28753126 http://dx.doi.org/10.7554/eLife.26067

Ejemplares similares

Immunoproteasome functions explained by divergence in cleavage specificity and regulation
por: Winter, Michael B, et al.
Publicado: (2017)

Heparin enhances the furin cleavage of HIV‐1 gp160 peptides
por: Pasquato, A., et al.
Publicado: (2007)

Tetramerisation of the CRISPR ring nuclease Crn3/Csx3 facilitates cyclic oligoadenylate cleavage
por: Athukoralage, Januka S, et al.
Publicado: (2020)

Deletion of the Highly Conserved N-Glycan at Asn260 of HIV-1 gp120 Affects Folding and Lysosomal Degradation of gp120, and Results in Loss of Viral Infectivity
por: Mathys, Leen, et al.
Publicado: (2014)

The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase
por: Bolduc, David M, et al.
Publicado: (2016)

LRET-derived HADDOCK structural models describe the conformational heterogeneity required for DNA cleavage by the Mre11-Rad50 DNA damage repair complex
por: Canny, Marella D, et al.
Publicado: (2022)

Destabilization of EpCAM dimer is associated with increased susceptibility towards cleavage by TACE
por: Žagar, Tomaž, et al.
Publicado: (2021)

Roles of the membrane-reentrant β-hairpin-like loop of RseP protease in selective substrate cleavage
por: Akiyama, Koichiro, et al.
Publicado: (2015)

Human Holliday junction resolvase GEN1 uses a chromodomain for efficient DNA recognition and cleavage
por: Lee, Shun-Hsiao, et al.
Publicado: (2015)

The neuroprotective effect of nicotine in Parkinson’s disease models is associated with inhibiting PARP-1 and caspase-3 cleavage
por: Lu, Justin Y.D., et al.
Publicado: (2017)

Demonstration of Proteolytic Activation of the Epithelial Sodium Channel (ENaC) by Combining Current Measurements with Detection of Cleavage Fragments
por: Krappitz, Matteus, et al.
Publicado: (2014)

RISC-interacting clearing 3’- 5’ exoribonucleases (RICEs) degrade uridylated cleavage fragments to maintain functional RISC in Arabidopsis thaliana
por: Zhang, Zhonghui, et al.
Publicado: (2017)

The carbohydrate at asparagine 386 on HIV-1 gp120 is not essential for protein folding and function but is involved in immune evasion
por: Sanders, Rogier W, et al.
Publicado: (2008)

Supplementary data for the mechanism for cleavage of three typical glucosidic bonds induced by hydroxyl free radical
por: Dai, Yujie, et al.
Publicado: (2017)

The shape of the bacterial ribosome exit tunnel affects cotranslational protein folding
por: Kudva, Renuka, et al.
Publicado: (2018)

Residue-by-residue analysis of cotranslational membrane protein integration in vivo
por: Nicolaus, Felix, et al.
Publicado: (2021)

Convergent HIV-1 Evolution upon Targeted Destabilization of the gp120-gp41 Interface
por: Torrents de la Peña, Alba, et al.
Publicado: (2021)

Structural and mutational analysis of the ribosome-arresting human XBP1u
por: Shanmuganathan, Vivekanandan, et al.
Publicado: (2019)

Viral genome cleavage with artificial ribonucleases: A new method to inactivate RNA-containing viruses
por: Goncharova, E. P., et al.
Publicado: (2009)

Cleavage Patterns of 9600 Embryos: The Importance of Irregular Cleavage
por: Shavit, Maya, et al.
Publicado: (2023)

Phosphorylation of tyrosine 90 in SH3 domain is a new regulatory switch controlling Src kinase
por: Koudelková, Lenka, et al.
Publicado: (2023)

Strict conformational demands of RNA cleavage in bulge-loops created by peptidyl-oligonucleotide conjugates
por: Staroseletz, Yaroslav, et al.
Publicado: (2020)

Cryptosporidium parvum rhomboid1 has an activity in microneme protein CpGP900 cleavage
por: Li, Mingying, et al.
Publicado: (2016)

VvmiR160s/VvARFs interaction and their spatio-temporal expression/cleavage products during GA-induced grape parthenocarpy
por: Zhang, Wenying, et al.
Publicado: (2019)

“Bind, cleave and leave”: multiple turnover catalysis of RNA cleavage by bulge–loop inducing supramolecular conjugates
por: Amirloo, Bahareh, et al.
Publicado: (2021)

Orienting early cleavage
por: LeBrasseur, Nicole
Publicado: (2005)

Cleavage furrow positioning
por: Glotzer, Michael
Publicado: (2004)

Cleavage of the Glycoprotein of Arenaviruses
por: Pasquato, Antonella, et al.
Publicado: (2018)

Discrete Cleavage Motifs of Constitutive and Immunoproteasomes Revealed by Quantitative Analysis of Cleavage Products
por: Toes, R.E.M., et al.
Publicado: (2001)

Cleavage speed and implantation potential of early-cleavage embryos in IVF or ICSI cycles
por: Lee, Meng-Ju, et al.
Publicado: (2012)

Investigation on the processing and improving the cleavage efficiency of furin cleavage sites in Pichia pastoris
por: Huang, Yide, et al.
Publicado: (2018)

Coupling the core of the anticancer drug etoposide to an oligonucleotide induces topoisomerase II-mediated cleavage at specific DNA sequences
por: Infante Lara, Lorena, et al.
Publicado: (2018)

A phosphate-targeted dinuclear Cu(II) complex combining major groove binding and oxidative DNA cleavage
por: Molphy, Zara, et al.
Publicado: (2018)

The effect of adenine protonation on RNA phosphodiester backbone bond cleavage elucidated by deaza-nucleobase modifications and mass spectrometry
por: Fuchs, Elisabeth, et al.
Publicado: (2019)

Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice
por: Shin, Seung-Wook, et al.
Publicado: (2017)

Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site
por: Rosen, Laura E., et al.
Publicado: (2019)

A cleavage-based surrogate reporter for the evaluation of CRISPR–Cas9 cleavage efficiency
por: Jung, Soo Bin, et al.
Publicado: (2021)

Comparative Immunogenicity of HIV-1 gp160, gp140 and gp120 Expressed by Live Attenuated Newcastle Disease Virus Vector
por: Khattar, Sunil K., et al.
Publicado: (2013)

Measurement of the cleavage energy of graphite
por: Wang, Wen, et al.
Publicado: (2015)

Efficient Cleavage of Permethylated Cyclodextrins
por: Ishida, Yuki, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_o29h2scvjdhgik1b3lsb72jdgp