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Finding a Balance between Protection and Pathology: The Dual Role of Perforin in Human Disease
Perforin is critical for controlling viral infection and tumor surveillance. Clinically, mutations in perforin are viewed as unfavorable, as lack of this pore-forming protein results in lethal, childhood disease, familial hemophagocytic lymphohistiocytosis type 2 (FHL 2). However, many mutations in...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578000/ https://www.ncbi.nlm.nih.gov/pubmed/28757574 http://dx.doi.org/10.3390/ijms18081608 |