Toll-Like Receptor-4 Inhibitor TAK-242 Attenuates Motor Dysfunction and Spinal Cord Pathology in an Amyotrophic Lateral Sclerosis Mouse Model

Neuroinflammation contributes to amyotrophic lateral sclerosis (ALS) progression. TLR4, a transmembrane protein that plays a central role in activation of the innate immune system, has been shown to induce microglial activation in ALS models. TLR4 is up-regulated in the spinal cords of hSOD1(G93A) m...

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Detalles Bibliográficos
Autores principales: Fellner, Avi, Barhum, Yael, Angel, Ariel, Perets, Nisim, Steiner, Israel, Offen, Daniel, Lev, Nirit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578056/
https://www.ncbi.nlm.nih.gov/pubmed/28763002
http://dx.doi.org/10.3390/ijms18081666

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578056/
https://www.ncbi.nlm.nih.gov/pubmed/28763002
http://dx.doi.org/10.3390/ijms18081666

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