Modeling the Colchicum autumnale Tubulin and a Comparison of Its Interaction with Colchicine to Human Tubulin

Tubulin is the target for many small-molecule natural compounds, which alter microtubules dynamics, and lead to cell cycle arrest and apoptosis. One of these compounds is colchicine, a plant alkaloid produced by Colchicum autumnale. While C. autumnale produces a potent cytotoxin, colchicine, and exp...

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Detalles Bibliográficos
Autores principales: Spasevska, Ivana, Ayoub, Ahmed T., Winter, Philip, Preto, Jordane, Wong, Gane K.-S., Dumontet, Charles, Tuszynski, Jack A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578066/
https://www.ncbi.nlm.nih.gov/pubmed/28767055
http://dx.doi.org/10.3390/ijms18081676

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578066/
https://www.ncbi.nlm.nih.gov/pubmed/28767055
http://dx.doi.org/10.3390/ijms18081676

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