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Modeling the Colchicum autumnale Tubulin and a Comparison of Its Interaction with Colchicine to Human Tubulin

Tubulin is the target for many small-molecule natural compounds, which alter microtubules dynamics, and lead to cell cycle arrest and apoptosis. One of these compounds is colchicine, a plant alkaloid produced by Colchicum autumnale. While C. autumnale produces a potent cytotoxin, colchicine, and exp...

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Detalles Bibliográficos
Autores principales:	Spasevska, Ivana, Ayoub, Ahmed T., Winter, Philip, Preto, Jordane, Wong, Gane K.-S., Dumontet, Charles, Tuszynski, Jack A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578066/ https://www.ncbi.nlm.nih.gov/pubmed/28767055 http://dx.doi.org/10.3390/ijms18081676

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