Design and In Vitro Evaluation of a Cytotoxic Conjugate Based on the Anti-HER2 Affibody Fused to the Fc Fragment of IgG1

In our previous work we demonstrated that a small protein called affibody can be used for a cytotoxic conjugate development. The anti-HER2 affibody was armed with one moiety of a highly potent auristatin E and specifically killed HER2-positive cancer cells with a nanomolar IC(50). The aim of this st...

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Detalles Bibliográficos
Autores principales: Sochaj-Gregorczyk, Alicja M., Ludzia, Patryk, Kozdrowska, Emilia, Jakimowicz, Piotr, Sokolowska-Wedzina, Aleksandra, Otlewski, Jacek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578078/
https://www.ncbi.nlm.nih.gov/pubmed/28771178
http://dx.doi.org/10.3390/ijms18081688

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578078/
https://www.ncbi.nlm.nih.gov/pubmed/28771178
http://dx.doi.org/10.3390/ijms18081688

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