Single-Construct Polycistronic Doxycycline-Inducible Vectors Improve Direct Cardiac Reprogramming and Can Be Used to Identify the Critical Timing of Transgene Expression

Direct reprogramming is a promising approach in regenerative medicine. Overexpression of the cardiac transcription factors Gata4, Mef2c, and Tbx5 (GMT) or GMT plus Hand2 (GHMT) directly reprogram fibroblasts into cardiomyocyte-like cells (iCMs). However, the critical timing of transgene expression a...

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Detalles Bibliográficos
Autores principales: Umei, Tomohiko C., Yamakawa, Hiroyuki, Muraoka, Naoto, Sadahiro, Taketaro, Isomi, Mari, Haginiwa, Sho, Kojima, Hidenori, Kurotsu, Shota, Tamura, Fumiya, Osakabe, Rina, Tani, Hidenori, Nara, Kaori, Miyoshi, Hiroyuki, Fukuda, Keiichi, Ieda, Masaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578192/
https://www.ncbi.nlm.nih.gov/pubmed/28825623
http://dx.doi.org/10.3390/ijms18081805

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578192/
https://www.ncbi.nlm.nih.gov/pubmed/28825623
http://dx.doi.org/10.3390/ijms18081805

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