Genome-Wide RNAi Ionomics Screen Reveals New Genes and Regulation of Human Trace Element Metabolism

Trace elements are essential for human metabolism and dysregulation of their homeostasis is associated with numerous disorders. Here we characterize mechanisms that regulate trace elements in human cells by designing and performing a genome-wide high-throughput siRNA/ionomics screen, and examining t...

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Detalles Bibliográficos
Autores principales: Malinouski, Mikalai, Hasan, Nesrin M., Zhang, Yan, Seravalli, Javier, Lin, Jie, Avanesov, Andrei, Lutsenko, Svetlana, Gladyshev, Vadim N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578452/
https://www.ncbi.nlm.nih.gov/pubmed/24522796
http://dx.doi.org/10.1038/ncomms4301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578452/
https://www.ncbi.nlm.nih.gov/pubmed/24522796
http://dx.doi.org/10.1038/ncomms4301

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