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Pulling MscL open via N-terminal and TM1 helices: A computational study towards engineering an MscL nanovalve

There are great opportunities in the manipulation of bacterial mechanosensitive (MS) ion channels for specific and targeted drug delivery purposes. Recent research has shown that these ion channels have the potential to be converted into nanovalves through clever use of magnetic nanoparticles and ma...

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Detalles Bibliográficos
Autores principales: Martinac, Adam D., Bavi, Navid, Bavi, Omid, Martinac, Boris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578686/
https://www.ncbi.nlm.nih.gov/pubmed/28859093
http://dx.doi.org/10.1371/journal.pone.0183822