Polymodal allosteric regulation of Type 1 Serine/Threonine Kinase Receptors via a conserved electrostatic lock

Type 1 Serine/Threonine Kinase Receptors (STKR1) transduce a wide spectrum of biological signals mediated by TGF-β superfamily members. The STKR1 activity is tightly controlled by their regulatory glycine-serine rich (GS) domain adjacent to the kinase domain. Despite decades of studies, it remains u...

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Detalles Bibliográficos
Autores principales: Botello-Smith, Wesley M., Alsamarah, Abdelaziz, Chatterjee, Payal, Xie, Chen, Lacroix, Jerome J., Hao, Jijun, Luo, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578689/
https://www.ncbi.nlm.nih.gov/pubmed/28827795
http://dx.doi.org/10.1371/journal.pcbi.1005711

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578689/
https://www.ncbi.nlm.nih.gov/pubmed/28827795
http://dx.doi.org/10.1371/journal.pcbi.1005711

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