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Two separate pathways regulate protein stability of ATM/ATR-related protein kinases Mec1 and Tel1 in budding yeast

Checkpoint signaling requires two conserved phosphatidylinositol 3-kinase-related protein kinases (PIKKs): ATM and ATR. In budding yeast, Tel1 and Mec1 correspond to ATM and ATR, respectively. The Tel2-Tti1-Tti2 (TTT) complex connects to the Rvb1-Rvb2-Tah1-Pih1 (R2TP) complex for the protein stabili...

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Detalles Bibliográficos
Autores principales:	Goto, Greicy H., Ogi, Hiroo, Biswas, Himadri, Ghosh, Avik, Tanaka, Seiji, Sugimoto, Katsunori
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578694/ https://www.ncbi.nlm.nih.gov/pubmed/28827813 http://dx.doi.org/10.1371/journal.pgen.1006873

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