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Two separate pathways regulate protein stability of ATM/ATR-related protein kinases Mec1 and Tel1 in budding yeast
Checkpoint signaling requires two conserved phosphatidylinositol 3-kinase-related protein kinases (PIKKs): ATM and ATR. In budding yeast, Tel1 and Mec1 correspond to ATM and ATR, respectively. The Tel2-Tti1-Tti2 (TTT) complex connects to the Rvb1-Rvb2-Tah1-Pih1 (R2TP) complex for the protein stabili...
Autores principales: | Goto, Greicy H., Ogi, Hiroo, Biswas, Himadri, Ghosh, Avik, Tanaka, Seiji, Sugimoto, Katsunori |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578694/ https://www.ncbi.nlm.nih.gov/pubmed/28827813 http://dx.doi.org/10.1371/journal.pgen.1006873 |
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