PIK3CA exon9 mutations associate with reduced survival, and are highly concordant between matching primary tumors and metastases in endometrial cancer

Mutations of the phosphoinositide-3-kinase (PI3K) catalytic subunit alpha gene (PIK3CA) are frequent in endometrial cancer. We sequenced exon9 and exon20 of PIK3CA in 280 primary endometrial cancers to assess the relationship with clinicopathologic variables, patient survival and associations with P...

Descripción completa

Detalles Bibliográficos
Autores principales: Mjos, Siv, Werner, Henrica M. J., Birkeland, Even, Holst, Frederik, Berg, Anna, Halle, Mari K., Tangen, Ingvild L., Kusonmano, Kanthida, Mauland, Karen K., Oyan, Anne M., Kalland, Karl-Henning, Lewis, Aurélia E., Mills, Gordon B., Krakstad, Camilla, Trovik, Jone, Salvesen, Helga B., Hoivik, Erling A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578954/
https://www.ncbi.nlm.nih.gov/pubmed/28860563
http://dx.doi.org/10.1038/s41598-017-10717-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578954/
https://www.ncbi.nlm.nih.gov/pubmed/28860563
http://dx.doi.org/10.1038/s41598-017-10717-z

Ejemplares similares